Anyone that has ever dieted (who hasn't?) knows it is hard, incredibly hard. And at times it can feel like an exercise in futility. And if you have followed all the diet advice to the letter (take in fewer calories than you consume, eat small meals throughout the day, avoid carbs and sugar, exercise daily, don't eat after 7pm, etc. etc.) only to end up frustrated and right back where you started, you are not alone. The fact is, most diets do work. You can lose the weight if you restrict your diet and increase your calorie burn. The problem is keeping it off long term and this is where most diets fail. Unfortunately, scientists are still trying to understand how the body responds to an energy imbalance over time and the knowledge is far from complete. A new study to be published in the New England Journal of Medicine and profiled in the NYTimes , demonstrates how the body's own hormones work against permanent weight loss. Leptin, a hormone that is directly prop...